Brock Purdy’s likely absence looms large as San Francisco visits New Orleans, nudging Kyle Shanahan to lean on the run and Christian McCaffrey while M. Jones steps in to see how far the system can carry a backup.

The Saints counter with Alvin Kamara handling early-down workload and Ricky Pearsall stepping into a bigger pass-game role, supported by Brandon Cooks and Rashid Shaheed in the WR mix. George Kittle’s hamstring and Trent Williams’ health shape the game’s passing lanes and protection, making this a trench-forward, grind-it-out affair with fantasy implications everywhere.

Expect SF to stack the box and feed McCaffrey, while New Orleans tries to tilt the field through Kamara and Pearsall in quick-hitting throws. The outcome hinges on the run game, turnover avoidance, and which offense can sustain drives behind reshuffled personnel and a splintered receiving corps.

San Francisco heads to New Orleans with Brock Purdy status in doubt and M. Jones waiting as insurance. Christian McCaffrey remains the engine, while George Kittle’s hamstring and Brandon Aiyuk’s IR cloud the passing game. The 49ers lean into a run-first script and try to deploy 12-personnel to stall the Saints’ front. KC’s Worthy status looms in the background as Kansas City navigates a high-profile clash with Philadelphia, while Philly’s Jalen Carter suspension adds a deeper subplot for dynasty and DFS alike.

Jackson Smith-Njigba paced Week 1 targets with a dominant 59% share, signaling a ceiling-raising role in Seattle’s passing game against the Steelers. Seattle’s multiple weapons should keep JSN's target volume high, bumping him toward weekly top-10 consideration in PPR formats.

Jakobi Meyers projects as Las Vegas’ primary Week 2 option, especially in a Chargers matchup where volume and quick-hitting targets could compile a steady floor. Stefon Diggs looks to remain a high-floor staple for Buffalo, while Travis Etienne’s resurgence adds a bullish upside for Jacksonville. Keenan Allen’s route-heavy role keeps him in the WR2/1 mix for half-PPR leagues.